N,N,3-trimethylpyrrolidin-3-amine → 2-[4-(3-Dimethylamino-3-methyl-pyrrolidin-1-yl)-3-fluorophenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	N,N,3-trimethylpyrrolidin-3-amine	HCID 45489883	—
Reactant	2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one	HCID 68991216	—
Product	2-[4-(3-Dimethylamino-3-methyl-pyrrolidin-1-yl)-3-fluorophenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one	HCID 57916633	—

Reaction Steps

2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one and dimethyl-(3-methyl-pyrrolidin-3-yl)-amine were reacted according to Method R1. In this way the product was obtained with molecular weight 465.57 (C27H32FN3O3); MS (ESI): 466 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-81746f0d5eb84210808a90111691f95d
Source note	uspto-grants-2014_09