反应详情

A solution of (1-benzyl-3-methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester (682 mg) in aqueous formic acid/aqueous formaldehyde 1:2 (7 mL) was stirred at 90° C. for 4 h. The mixture was neutralized with sodium hydroxide solution, extracted with dichloromethane, dried over magnesium sulfate and concentrated. The residue was purified by preparative HPLC. In this way the product was obtained with molecular weight 218.34 (C14H22N2); MS (ESI): 219 (M+H+).

1. extractionextracted with dichloromethane
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified by preparative HPLC
5. customIn this way the product was obtained with molecular weight 218.34 (C14H22N2)