反应详情

温度

0 °C

A solution of periodic acid in water (0.5 M; 5.2 mL) was added at 0° C. to a solution of 2-hydroxy-5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one (581 mg) in water/THF 1:1 (12 mL) and the solution was stirred at 0° C. for 1 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was purified by preparative HPLC. In this way the product was obtained with molecular weight 264.28 (C14H16O5); MS (ESI): 265 (M+H+).

1. extractionwas extracted with ether
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified by preparative HPLC
5. customIn this way the product was obtained with molecular weight 264.28 (C14H16O5)