反应详情

温度

100 °C

A mixture of 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one (1.25 g), acetic anhydride (3 mL), lead acetate (3.58 g) and acetic acid (3 mL) was stirred for 48 h at 100° C. After adding sodium carbonate solution it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 290.32 (C16H18O5); MS (ESI): 291 (M+H+).

1. extractionwas extracted with ether
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was chromatographed on silica gel
5. customIn this way the product was obtained with molecular weight 290.32 (C16H18O5)