HCID 20725688, compound → [(R)-1-(2-Fluoro-4-{1-oxo-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-1H-isoquinolin-2-yl}-phenyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

HRID 69509Notes

Reaction equation

HRID 69509 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C@@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][C:14]=2[F:20])[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[O:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][O:28][C:29]1[CH:30]=[C:31]2[C:36](=[CH:37][CH:38]=1)[C:35](=O)[O:34][CH2:33][CH2:32]2>>[C:1]([O:5][C:6](=[O:21])[NH:7][C@@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:33][CH2:32][C:31]4[C:36](=[CH:37][CH:38]=[C:29]([O:28][CH2:27][C@@H:23]5[CH2:24][CH2:25][CH2:26][O:22]5)[CH:30]=4)[C:35]3=[O:34])=[CH:15][C:14]=2[F:20])[CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 20725688HCID 20725688, compoundHCID 666799246-[(S)-1-(Tetrahydrofuran-2-yl)methoxy]isochroman-1-one

Product 1

HCID 86635108[(R)-1-(2-Fluoro-4-{1-oxo-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-1H-isoquinolin-2-yl}-phenyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Procedure

[(R)-1-(4-Amino-2-fluoro-phenyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester was reacted with 6-[(S)-1-(Tetrahydro-furan-2-yl)methoxy]-isochroman-1-one by method AC. The product with the molecular weight of 525.63 (C29H36FN3O5) was obtained in this way; MS (ESI): 526 (M+H+).

Workup

  1. customThe product with the molecular weight of 525.63 (C29H36FN3O5) was obtained in this way

Sources & evidence

ORD record
ord-34bec340643a4d7cbbeb2dadd5067aa9
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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