HRID69511

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66679924

未命名化合物

结构：CC1(O)CCN([C@@H]2CCN(c3ccc(N)cc3F)C2)CC1

HCID68990639

未命名化合物

PRODUCTS

生成物

结构：CC1(O)CCN([C@@H]2CCN(c3ccc(N4CCc5cc(OC[C@@H]6CCCO6)ccc5C4=O)cc3F)C2)CC1

HCID57916891

未命名化合物

PROCEDURE

实验过程

1-[(R)-1-(4-Amino-2-fluoro-phenyl)-pyrrolidin-3-yl]-4-methyl-piperidin-4-ol was reacted with 6-[(S)-1-(Tetrahydro-furan-2-yl)methoxy]-isochroman-1-one by method AC. The product with the molecular weight of 523.65 (C30H38FN3O4) was obtained in this way; MS (ESI): 524 (M+H+).

WORKUP

后处理

customThe product with the molecular weight of 523.65 (C30H38FN3O4) was obtained in this way

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5f86081235cc4d8ba012c513812c2ded
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822495B2
来源说明: uspto-grants-2014_09

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@@H:10]([N:13]3[CH2:18][CH2:17][C:16]([CH3:20])([OH:19])[CH2:15][CH2:14]3)[CH2:9]2)=[C:4]([F:21])[CH:3]=1.[O:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][O:28][C:29]1[CH:30]=[C:31]2[C:36](=[CH:37][CH:38]=1)[C:35](=O)[O:34][CH2:33][CH2:32]2>>[F:21][C:4]1[CH:3]=[C:2]([N:1]2[CH2:33][CH2:32][C:31]3[C:36](=[CH:37][CH:38]=[C:29]([O:28][CH2:27][C@@H:23]4[CH2:24][CH2:25][CH2:26][O:22]4)[CH:30]=3)[C:35]2=[O:34])[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:12][CH2:11][C@@H:10]([N:13]2[CH2:14][CH2:15][C:16]([OH:19])([CH3:20])[CH2:17][CH2:18]2)[CH2:9]1