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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 6952Generated: October 26, 2026

tert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylate → [2-(1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester

https://huagongshe.com/reaction/6952

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylateHCID 10583745—
Reactant3-(1H-Indol-4-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl esterHCID 69368098—
Product[2-(1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl esterHCID 10708626—

Reaction Steps

In a similar manner, using 3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester in place of (2-hydroxy-ethyl)-methyl-carbamic acid tert-butyl ester, 3-(1H-Indol-4-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester was prepared, (25%), (M−H)−=301.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07084169B2
Source datasetuspto-grants-2006_08
ORD IDord-0e9e8d5c94114eeeb2ac26b063c4d5b9
Source noteuspto-grants-2006_08