1,2-Dideoxyribofuranose → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-((2R,3S)-3-hydroxy-tetrahydro-furan-2-ylmethoxy)-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	1,2-Dideoxyribofuranose	HCID 124657	—
Reactant	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one	HCID 68989350	—
Product	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-((2R,3S)-3-hydroxy-tetrahydro-furan-2-ylmethoxy)-2H-isoquinolin-1-one	HCID 57916770	—

Reaction Steps

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with (2R,3S)-2-Hydroxymethyl-tetrahydro-furan-3-ol by method Y. The product with the molecular weight of 493.58 (C28H32FN3O4) was obtained in this way; MS (ESI): 494 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-aa1551515af247299b1897797468aa50
Source note	uspto-grants-2014_09