Hexylene Glycol → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(3-hydroxy-1,3-dimethyl-butoxy)-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	Hexylene Glycol	HCID 7870	—
Reactant	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one	HCID 68989350	—
Product	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(3-hydroxy-1,3-dimethyl-butoxy)-2H-isoquinolin-1-one	HCID 57916769	—

Reaction Steps

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 2-Methyl-pentane-2,4-diol by method Y. The product with the molecular weight of 493.63 (C29H36FN3O3) was obtained in this way; MS (ESI): 494 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-2d5940d21e804c8880f76ee5740d8177
Source note	uspto-grants-2014_09