4-(Bromomethyl)oxane → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(tetrahydro-pyran-4-ylmethoxy)-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	4-(Bromomethyl)oxane	HCID 2773286	—
Reactant	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one	HCID 68989350	—
Product	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(tetrahydro-pyran-4-ylmethoxy)-2H-isoquinolin-1-one	HCID 57916900	—

Reaction Steps

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 4-Bromomethyl-tetrahydro-pyran by method K. The product with the molecular weight of 491.61 (C29H34FN3O3) was obtained in this way; MS (ESI): 492 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-4b83a62b467644a9817b9dcc490d030f
Source note	uspto-grants-2014_09