HRID69528
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 80 °C
PROCEDURE
实验过程
To a solution of example 2 (0.05 g, 86.4 μmol, Eq: 1.00) in refluxing methanol (1 ml) was added methyl iodide (9.2 mg, 4.05 μl, 64.8 μmol, Eq: 0.75). After complete addition the mixture was stirred at 80° C. for 2 h. Additional methyl iodide (9.2 mg, 4.05 μl, 64.8 μmol, Eq: 0.75) was added and the mixture was stirred at 80° C. for 2 h, then at 20° C. over night. The mixture was purified by preparative HPLC to yield a colorless solid (3 mg; 6%). m/z=592.2 [M+H]+.
WORKUP
后处理
- additionAfter complete addition the mixture
- stirringthe mixture was stirred at 80° C. for 2 h
- waitat 20° C. over night
- customThe mixture was purified by preparative HPLC
- customto yield a colorless solid (3 mg; 6%)