Hydrochloric Acid → HCID 69367839, compound

Participants

Reaction Conditions

Reaction Steps

2-Benzenesulfonyl-4-[2-(tert-butoxycarbonyl-methyl-amino)-ethoxy]-indole-1-carboxylic acid tert-butyl ester (0.250 g., 0.5 mmol) from Step 3 was dissolved in 5 mL EtOH. To this solution was added 1 mL of 2M ethanolic hydrogen chloride solution. The reaction mixture was heated at 100° C. for 35 minutes. Upon cooling to ambient temperature, a fine white precipitate was observed. After filtration and drying in vacuo at 60° C., [2-(2-benzenesulfonyl-1H-indol-4-yloxy)-ethyl]-methyl-amine hydrochloride was obtained. MS: 330 (M+H)+, mp=250.7–252.1° C.

Provenance & Evidence