ethyl [4-bromo-3-(4,5-difluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetate → Ethyl(4'-bromo-5,6-difluoro-2'-oxospiro[1-benzofuran-3,3'-indol]-1'(2'h)-yl)acetate

HRID 695418Notes

Reaction equation

HRID 695418 reaction equation
[Br:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[N:6]([CH2:11][C:12](=[O:13])[O:14][CH2:15][CH3:16])[C:5](=[O:17])[C:4]2([CH2:18][OH:19])[c:20]1[c:21]([OH:28])[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]1.[CH:29]1([CH2:30][CH2:31][N:32]2[c:33]3[c:34]([cH:35][cH:36][cH:37][cH:38]3)[C:39]([c:40]3[c:41]([OH:42])[cH:43][c:44]4[c:48]([cH:49]3)[O:47][CH2:46][O:45]4)([CH2:50][OH:51])[C:52]2=[O:53])[CH2:54][CH2:55]1>>[Br:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[N:6]([CH2:11][C:12](=[O:13])[O:14][CH2:15][CH3:16])[C:5](=[O:17])[C:4]21[CH2:18][O:19][c:21]2[c:20]1[cH:25][c:24]([F:26])[c:23]([F:27])[cH:22]2

Participants

3

Reactant 2

HCID 58872533ethyl [4-bromo-3-(4,5-difluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetateHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 59263373Ethyl(4'-bromo-5,6-difluoro-2'-oxospiro[1-benzofuran-3,3'-indol]-1'(2'h)-yl)acetate

Sources & evidence

ORD record
ord-c038de8ef9824523817209056cde3b13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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