4-Amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid → 1-(Tert-butoxycarbonyl)-4-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)amino]piperidine-4-carboxylic acid
Reaction equation
[Cl:1][c:2]1[c:3]([F:23])[c:4]([NH:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([O:18][CH3:19])[c:13]([CH:16]=[O:17])[cH:14][c:15]23)[cH:20][cH:21][cH:22]1.[NH2:24][C:25]1([C:38](=[O:39])[OH:40])[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]1>>[Cl:1][c:2]1[c:3]([F:23])[c:4]([NH:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([O:18][CH3:19])[c:13]([CH2:16][NH:24][C:25]4([C:38](=[O:39])[OH:40])[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]4)[cH:14][c:15]23)[cH:20][cH:21][cH:22]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-4369554ae5d94968943468ae52f35261
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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