HCID 17948959, compound → 4-(2,2-Difluoroethyl)pyrrolidin-2-one

HRID 69556Notes

Reaction equation

HRID 69556 reaction equation
[F:1][C:2]([F:10])=[CH:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1>[Pd].CO>[F:1][CH:2]([F:10])[CH2:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1

Participants

4

Reactant 1

HCID 17948959HCID 17948959, compound

Product 1

HCID 179489344-(2,2-Difluoroethyl)pyrrolidin-2-oneYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-(2,2-difluoroethenyl)pyrrolidin-2-one a1 (2.8 g, 18.77 mmol, 1 eq) and palladium on charcoal (10% Wt, 300 mg) in methanol (500 ml) is stirred overnight under an hydrogen atmosphere (40 psi) at room temperature. The reaction mixtured is filtered over celite and the solvent is removed under reduced pressure to afford 4-(2,2-difluoroethyl)pyrrolidin-2-one a11 which can be used in the next step without any further purification.

Workup

  1. customThe reaction
  2. filtrationmixtured is filtered over celite
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-f18b7aa74a03440a9e73c6b6bacb5116
Source dataset
uspto-grants-2014_09
Patent number
US08822508B2

Reaction notes

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