Ethyl bromoacetate → [2-(Benzylcarbamoyl-methyl)-1-(3,4-dimethoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-yloxy]-acetic acid ethyl ester

HRID 696117Notes

Reaction equation

HRID 696117 reaction equation
[Br:36][CH2:37][C:38](=[O:39])[O:40][CH2:41][CH3:42].[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH2:20][C:21](=[O:22])[NH:23][CH2:24][c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[CH2:9][CH2:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]32)[cH:31][cH:32][c:33]1[O:34][CH3:35]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH2:20][C:21](=[O:22])[NH:23][CH2:24][c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[CH2:9][CH2:10][c:11]3[cH:12][c:13]([O:19][CH2:37][C:38](=[O:39])[O:40][CH2:41][CH3:42])[c:14]([O:17][CH3:18])[cH:15][c:16]32)[cH:31][cH:32][c:33]1[O:34][CH3:35]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 227426232-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

Product 1

HCID 69894100[2-(Benzylcarbamoyl-methyl)-1-(3,4-dimethoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-yloxy]-acetic acid ethyl ester

Sources & evidence

ORD record
ord-e0b27a4e591145b1819529dcbd36000c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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