Methanol → 5-Bromo-3-(5-(4-(2-fluoroethyl)piperazin-1-yl)pyridin-2-ylamino)-1-methylpyridin-2(1H)-one
Reaction equation
[Br:17][c:18]1[c:19](=[O:26])[n:20]([CH3:25])[cH:21][c:22]([Br:24])[cH:23]1.[C:27](=[O:28])([O-:29])[O-:30].[CH2:33]1[O:34][CH2:35][CH2:36][O:37][CH2:38]1.[CH2:41]([Cl:42])[Cl:43].[CH3:39][OH:40].[Cs+:31].[Cs+:32].[F:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][N:7]([c:10]2[cH:11][cH:12][c:13]([NH2:16])[n:14][cH:15]2)[CH2:8][CH2:9]1.[O:47]=[C:48]([CH:49]=[CH:50][c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1)[CH:57]=[CH:58][c:59]1[cH:60][cH:61][cH:62][cH:63][cH:64]1.[O:65]=[C:66]([CH:67]=[CH:68][c:69]1[cH:70][cH:71][cH:72][cH:73][cH:74]1)[CH:75]=[CH:76][c:77]1[cH:78][cH:79][cH:80][cH:81][cH:82]1.[O:83]=[C:84]([CH:85]=[CH:86][c:87]1[cH:88][cH:89][cH:90][cH:91][cH:92]1)[CH:93]=[CH:94][c:95]1[cH:96][cH:97][cH:98][cH:99][cH:100]1.[OH2:44].[Pd:45].[Pd:46]>>[F:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][N:7]([c:10]2[cH:11][cH:12][c:13]([NH:16][c:18]3[c:19](=[O:26])[n:20]([CH3:25])[cH:21][c:22]([Br:24])[cH:23]3)[n:14][cH:15]2)[CH2:8][CH2:9]1Participants
11
Reactant 10
Product 1
Sources & evidence
- ORD record
- ord-98ea71e349a54cce87b3d058e93aaa50
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
Loading…