Pyridine → N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-furansulfonamide

HRID 696596Notes

Reaction equation

HRID 696596 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:26])[c:21]([NH2:22])[cH:23][cH:24][cH:25]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1.[Cl:42][CH2:43][Cl:44].[cH:27]1[cH:28][cH:29][n:30][cH:31][cH:32]1.[o:33]1[c:34]([S:38](=[O:39])(=[O:40])[Cl:41])[cH:35][cH:36][cH:37]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:26])[c:21]([NH:22][S:38]([c:34]4[o:33][cH:37][cH:36][cH:35]4)(=[O:39])=[O:40])[cH:23][cH:24][cH:25]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 2795072Furan-2-sulfonyl ChlorideHCID 579897213-(5-(2-Chloropyrimidin-4-yl)-2-morpholinothiazol-4-yl)-2-fluoroaniline

Product 1

HCID 57989659N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-furansulfonamide

Sources & evidence

ORD record
ord-4e35cde698bd42cfaf62edf8dd2e523b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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