5-(Cyclopropylmethoxy)pyrazine-2-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4,6,6-trimethyl-1,3-oxazin-4-yl)-4-fluorophenyl]-5-(cyclopropylmethoxy)pyrazine-2-carboxamide
Reaction equation
[CH:21]1([CH2:24][O:25][c:26]2[n:27][cH:28][c:29]([C:32](=[O:33])[OH:34])[n:30][cH:31]2)[CH2:22][CH2:23]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:20])[c:6]([C:8]2([CH3:19])[N:9]=[C:10]([NH2:18])[O:11][C:12]([CH3:16])([CH3:17])[C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:20])[c:6]([C:8]2([CH3:19])[N:9]=[C:10]([NH2:18])[O:11][C:12]([CH3:16])([CH3:17])[C:13]2([F:14])[F:15])[cH:7]1)[C:32]([c:29]1[cH:28][n:27][c:26]([O:25][CH2:24][CH:21]2[CH2:22][CH2:23]2)[cH:31][n:30]1)=[O:33]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-5706275e069f46e993ab782086f00855
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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