Potassium Carbonate → (S)-tert-butyl 4-(4-cyanophenyl)-2-methylpiperazine-1-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Fluorobenzonitrile	HCID 14517	—
반응물	tert-Butyl (2S)-2-methylpiperazine-1-carboxylate	HCID 10081508	—
용매	Ethyl Acetate	HCID 8857	—
생성물	(S)-tert-butyl 4-(4-cyanophenyl)-2-methylpiperazine-1-carboxylate	HCID 58324511	30%

반응 조건

온도	110 °C

반응 단계

(S)-tert-butyl 2-methylpiperazine-1-carboxylate (1 g, 4.99 mmol), 4-fluorobenzonitrile (0.605 g, 4.99 mmol), and K2CO3 (0.897 g, 6.49 mmol) were combined into a vial equipped with a stir bar. The reaction was heated to 110° C. for 48 h. Cooled to RT, diluted with EA and filtered. Concentrated to a clear oil and purified on silica gel (80 g, 10-20% EA in Hex) to give a clear oil (450 mg, 30% yield) which became a crystalline solid upon sitting. [M+H] calc'd for C17H23N3O2, 301; found, 301.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08822470B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-889aa208a12844829a3e24e638b7a825
출처 메모	uspto-grants-2014_09