6'-Bromo-4,4-difluoro-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine → 4,4-Difluoro-5''-methyl-6'-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

HRID 697064Notes

Reaction equation

HRID 697064 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:16]([cH:17]1)[C:15]1([C:7]3([CH2:6]2)[CH2:8][CH2:9][C:10]([F:13])([F:14])[CH2:11][CH2:12]3)[N:18]=[C:19]([CH3:23])[C:20]([NH2:22])=[N:21]1.[C:24](#[C:25][CH3:26])[c:27]1[cH:28][c:29]([B:33]([OH:34])[OH:35])[cH:30][n:31][cH:32]1>>[c:2]1(-[c:29]2[cH:28][c:27]([C:24]#[C:25][CH3:26])[cH:32][n:31][cH:30]2)[cH:3][cH:4][c:5]2[c:16]([cH:17]1)[C:15]1([C:7]3([CH2:6]2)[CH2:8][CH2:9][C:10]([F:13])([F:14])[CH2:11][CH2:12]3)[N:18]=[C:19]([CH3:23])[C:20]([NH2:22])=[N:21]1

Participants

3

Reactant 2

HCID 573858836'-Bromo-4,4-difluoro-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amineHCID 574164825-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 679793724,4-Difluoro-5''-methyl-6'-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Sources & evidence

ORD record
ord-46bf2f7b07b049c8874570edb7ffead8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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