Ethanol → tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

HRID 697165Notes

Reaction equation

HRID 697165 reaction equation
[CH3:19][CH2:20][OH:21].[OH-:22].[OH-:24].[OH:1][C:2]1([CH2:15][N+:16]([O-:17])=[O:18])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1.[Pd+2:23]>>[OH:1][C:2]1([CH2:15][NH2:16])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 53486300tert-Butyl 4-hydroxy-4-(nitromethyl)piperidine-1-carboxylate

Product 1

HCID 23396319tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-eeb8fedd23274f94b96cbdfb17e35ee8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…