Pyridine → 2-(4-Chloro-phenyl)-5-{3-methoxy-4-[1-(3,3,3-trifluoro-propionyl)-azetidin-3-yloxy]-phenyl]-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

HRID 697297Notes

Reaction equation

HRID 697297 reaction equation
[F:31][C:32]([CH2:33][C:34](=[O:35])[Cl:36])([F:37])[F:38].[NH:1]1[CH2:2][CH:3]([O:5][c:6]2[c:7]([O:29][CH3:30])[cH:8][c:9]([N:12]3[C:13](=[O:28])[c:14]4[c:15]([n:18][c:19](-[c:21]5[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]5)[s:20]4)[CH2:16][CH2:17]3)[cH:10][cH:11]2)[CH2:4]1.[cH:39]1[cH:40][cH:41][n:42][cH:43][cH:44]1>>[N:1]1([C:34]([CH2:33][C:32]([F:31])([F:37])[F:38])=[O:35])[CH2:2][CH:3]([O:5][c:6]2[c:7]([O:29][CH3:30])[cH:8][c:9]([N:12]3[C:13](=[O:28])[c:14]4[c:15]([n:18][c:19](-[c:21]5[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]5)[s:20]4)[CH2:16][CH2:17]3)[cH:10][cH:11]2)[CH2:4]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 27833433,3,3-Trifluoropropionyl chlorideHCID 249911625-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Product 1

HCID 249911672-(4-Chloro-phenyl)-5-{3-methoxy-4-[1-(3,3,3-trifluoro-propionyl)-azetidin-3-yloxy]-phenyl]-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Sources & evidence

ORD record
ord-bdaf9cfb899544569b4671abfd0d1857
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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