反应详情

温度

25 °C

A solution of N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide (35 mg, 73 μmol) in methanol (1 mL) was treated with 2M NaOH (0.3 mL, 0.6 mmol) and stirred at 25° C. for 30 min. The reaction mixture was treated with acetic acid (50 μL, 0.9 mmol), filtered, and purified by preparative LCMS to give the desired product (14 mg, 42%) as a solid. LCMS for C12H16BrFN7O4S (M+H)+: m/z=451.8, 453.9. 1H NMR (400 MHz, DMSO-d6): δ 11.5 (s, 1 H), 8.89 (s, 1H), 7.17 (dd, J=8.8, 8.6 Hz, 1 H), 7.09 (dd, J=6.1, 2.7 Hz, 1 H), 6.76-6.72 (m, 1 H), 6.56 (dd, J=6.1, 6.1 Hz, 1 H), 6.51 (s, 2 H), 6.17 (dd, J=5.9, 5.9 Hz, 1 H), 3.27-3.21 (m, 2 H), 2.94-2.88 (m, 2 H), 1.78-1.71 (m, 2 H).

1. filtrationfiltered
2. custompurified by preparative LCMS