HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(2-Aminoethyl)methanesulfonamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-Butyl {2-[(methanesulfonyl)amino]ethyl}carbamate | HCID 47454467 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-(2-Aminoethyl)methanesulfonamide dihydrochloride | HCID 86638021 | 100% |
Reaction Steps
tert-Butyl {2-[(methylsulfonyl)amino]ethyl}carbamate (21 g, 88 mmol) was stirred in a solution of 4N hydrogen chloride in 1,4-dioxane (97 mL, 388 mmol) for 30 minutes. Trituration with ethyl acetate and hexanes followed by diethyl ether and hexanes gave the desired compound as a gum (19 g, 100%). LCMS calculated for C3H11N2O2S (M+H)+: m/z=139.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822511B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3c6fcc808d944dd799c7671ba33ded4e |
| Source note | uspto-grants-2014_09 |