Ethanol → 4-[6-(2,4-difluoro-phenoxy)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-3-methyl-phenol
Reaction equation
[C:39](=[O:40])([O-:41])[O-:42].[CH3:51][CH2:52][OH:53].[F:1][c:2]1[c:3]([O:4][c:5]2[n:6][cH:7][c:8]3[c:9]([n:10]2)[n:11]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[n:12][c:13]3[I:14])[cH:23][cH:24][c:25]([F:27])[cH:26]1.[K+:43].[K+:44].[O:45]1[CH2:46][CH2:47][O:48][CH2:49][CH2:50]1.[OH2:54].[OH:28][c:29]1[cH:30][c:31]([CH3:38])[c:32]([B:35]([OH:36])[OH:37])[cH:33][cH:34]1.[cH:55]1[cH:56][cH:57][c:58]([P:59]([Pd:60]([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([P:80]([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[P:99]([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)([c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)[cH:130][cH:131]1>>[F:1][c:2]1[c:3]([O:4][c:5]2[n:6][cH:7][c:8]3[c:9]([n:10]2)[n:11]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[n:12][c:13]3-[c:32]2[c:31]([CH3:38])[cH:30][c:29]([OH:28])[cH:34][cH:33]2)[cH:23][cH:24][c:25]([F:27])[cH:26]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-bc1626e82f6a4cea9977598f2723c3c8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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