HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → tert-butyl N-[1-(3-nitro-4-pyridinyl)piperidin-3-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Chloro-3-nitropyridine | HCID 2735781 | — |
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Product | tert-butyl N-[1-(3-nitro-4-pyridinyl)piperidin-3-yl]carbamate | HCID 67499953 | 89% |
Reaction Steps
The method of Example 1 was followed using 1 eq each of 4-chloro-3-nitropyridine, 3-N-Boc-amino piperidine and diisopropylethylamine yielding tert-butyl 1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate, (89%). LCMS (m/z): 323.1 (MH+); LC Rt=2.13 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-48e3740169dd4e60a0d79513abd900bf |
| Source note | uspto-grants-2014_09 |