HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-Chloro-5-nitro-4-(piperidin-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2,4-Dichloro-5-nitropyrimidine | HCID 521266 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Chloro-5-nitro-4-(piperidin-1-yl)pyrimidine | HCID 7147257 | — |
Reaction Steps
Method 1 was followed using 2,4-dichloro-5-nitropyrimidine (1.0 eq), and piperidine (2.0 eq) in EtOH at 0° C. to rt, yielding after washing with 1M citric acid and 1M HCl (to remove the bis addition product), 2-chloro-5-nitro-4-(piperidin-1-yl)pyrimidine (67%) LCMS (m/z): 242.9 (MH+); LC Rt=4.09 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e8307f40214a44f987c44c5c386c7361 |
| Source note | uspto-grants-2014_09 |