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HRID69844

反应详情

EQUATION

反应方程式

HRID 69844 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1
HCID79596

4'-Chloro-3'-nitroacetophenone

C8H6ClNO3

结构：CC(C)(C)OC(=O)NC1CCNCC1
HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

PRODUCTS

生成物

1
结构：CC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1
HCID51119762

未命名化合物

收率 95%

PROCEDURE

实验过程

Method 1 was followed using 4-chloro-3-nitroacetophenone (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. overnight yielding tert-butyl 1-(4-acetyl-2-nitrophenyl)piperidin-4-ylcarbamate (95%). LCMS (m/z): 364.1 (MH+); LC Rt=2.99 min.

WORKUP

后处理

  1. customat 55° C.
  2. customovernight