HRID69846

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25140

Anisole, 4-chloro-3-nitro-

C7H6ClNO3

HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

PRODUCTS

生成物

结构：COc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1

HCID69044880

未命名化合物

收率 75%

PROCEDURE

实验过程

Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 60° C. for 72 hours yielding tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-4-ylcarbamate (75%). LCMS (m/z): 352.1 (MH+); LC Rt=3.22 min.

WORKUP

后处理

customat 60° C.
customfor 72 hours