HRID69850

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID136287

4-Fluoro-3-nitrotoluene

C7H6FNO2

HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

PRODUCTS

生成物

结构：Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1

HCID69042835

未命名化合物

收率 90%

PROCEDURE

实验过程

Method 1 was followed using 4-fluoro-3-nitrotoluene (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (1.5 eq) at 55° C. for 48 hours yielding tert-butyl 4-(4-methyl-2-nitrophenyl)piperazine-1-carboxylate (90%). LCMS (m/z): 322.1 (MH+); LC Rt=3.46 min.

WORKUP

后处理

customat 55° C.
customfor 48 hours