HRID69851

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID136287

4-Fluoro-3-nitrotoluene

C7H6FNO2

HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

PRODUCTS

生成物

结构：Cc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1

HCID69042348

未命名化合物

收率 87%

PROCEDURE

实验过程

Method 1 was followed using 4-fluoro-3-nitrotoluene (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (1.5 eq) at 55° C. for 48 hours yielding tert-butyl 1-(4-methyl-2-nitro phenyl)piperidin-4-ylcarbamate (87%). LCMS (m/z): 336.1 (MH+); LC Rt=3.32 min.

WORKUP

后处理

customat 55° C.
customfor 48 hours