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HRID69854

反应详情

EQUATION

反应方程式

HRID 69854 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])c1cc(C(F)(F)F)ccc1F
HCID67778

Benzene, 1-fluoro-2-nitro-4-(trifluoromethyl)-

C7H3F4NO2

结构：CC(C)(C)OC(=O)NC1CCNCC1
HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1
HCID60507337

未命名化合物

收率 99%

PROCEDURE

实验过程

Method 1 was followed using 1-fluoro-2-nitro-4-(trifluoromethyl)benzene (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. for 1 hour yielding tert-butyl 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-4-ylcarbamate (99%). LCMS (m/z): 390.1 (MH+); LC Rt=3.51 min.

WORKUP

后处理

  1. customat 55° C.
  2. customfor 1 hour