huagongshe.com
HRID69855

反应详情

EQUATION

反应方程式

HRID 69855 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])c1cc(C(F)(F)F)ccc1F
HCID67778

Benzene, 1-fluoro-2-nitro-4-(trifluoromethyl)-

C7H3F4NO2

结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1
HCID53426214

tert-Butyl 4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate

C16H20F3N3O4

收率 99%

PROCEDURE

实验过程

Method 1 was followed using 1-fluoro-2-nitro-4-(trifluoromethyl)benzene (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) at 55° C. for 1 hour yielding tert-butyl 4-(2-nitro-4-(trifluoro-methyl)phenyl)piperazine-1-carboxylate (99%). LCMS (m/z): 376.1 (MH+); LC Rt=3.58 min.

WORKUP

后处理

  1. customat 55° C.
  2. customfor 1 hour