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HRID69862

反应详情

EQUATION

反应方程式

HRID 69862 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC1CCNCC1
HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

结构：O=C(c1ccc(Cl)c([N+](=O)[O-])c1)C1CC1
HCID1268259

4-Chloro-3-nitrophenyl cyclopropyl ketone

C10H8ClNO3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1CCN(c2ccc(C(=O)C3CC3)cc2[N+](=O)[O-])CC1
HCID69090083

未命名化合物

收率 95%

PROCEDURE

实验过程

Method 1 was followed using 4-chloro-3-nitrophenyl cyclopropyl ketone (1.0 eq), 4-(N-Boc-amino)piperidine (1.2 eq), and TEA (1.5 eq) at 55° C. for 48 hours yielding tert-butyl 1-(4-(cyclopropanecarbonyl)-2-nitrophenyl)piperidin-4-ylcarbamate (95%). LCMS (m/z): 390.1 (MH+); LC Rt=3.25 min.

WORKUP

后处理

  1. customat 55° C.
  2. customfor 48 hours