HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 6-amino-5-(piperidin-1-yl)pyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 178509018 | HCID 178509018 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-amino-5-(piperidin-1-yl)pyrimidin-2(1H)-one | HCID 69042258 | 89% |
Reaction Steps
Method 8 was followed using 1 eq. of 5-bromocytosine and 15 eq. of piperidine (as solvent). The reaction was cooled and added to CH2Cl2 and H2O. The solid was filtered, rinsed with H2O, and dried yielding 6-amino-5-(piperidin-1-yl)pyrimidin-2(1H)-one as a solid (89%). LCMS (m/z): 195.0 (MH+); LC Rt=1.28 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c9956fc30bc6468db63a70942c8e0fc7 |
| Source note | uspto-grants-2014_09 |