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HRID69884

反应详情

EQUATION

反应方程式

HRID 69884 的结构方程式

REACTANTS

反应物

2
结构：Nc1ncc(Br)nc1C(=O)O
HCID18521600

3-Amino-6-bromopyrazine-2-carboxylic acid

C5H4BrN3O2

结构：COc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c(N)c1
HCID69043362

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c(NC(=O)c2nc(Br)cnc2N)c1
HCID86669183

未命名化合物

收率 7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Following method 11, tert-butyl 1-(2-amino-4-methoxyphenyl)piperidin-4-ylcarbamate was coupled to 3-amino-6-bromopyrazine-2-carboxylic acid with TEA (3 eq) in ACN at 55° C. for 48 hours. Concentrated, triturated in cold ACN, filtered, and dried in vacuo yielding tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-methoxyphenyl)piperidin-4-ylcarbamate (7%). LCMS (m/z): 521.1 (MH+); LC Rt=3.63 min.

WORKUP

后处理

  1. concentrationConcentrated
  2. customtriturated in cold ACN
  3. filtrationfiltered
  4. customdried in vacuo