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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 69886Generated: October 27, 2026

4-(Piperidin-1-yl)pyridin-3-amine → 3,5-diamino-6-chloro-N-(4-(piperidin-1-yl)pyridin-3-yl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/69886

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Piperidin-1-yl)pyridin-3-amineHCID 348638—
Reactant3,5-Diamino-6-chloro-pyrazine acidHCID 6452119—
Product3,5-diamino-6-chloro-N-(4-(piperidin-1-yl)pyridin-3-yl)pyrazine-2-carboxamideHCID 8666918576%

Reaction Steps

Following method 11, 4-(piperidin-1-yl)pyridin-3-amine was coupled to 3,5-diamino-6-chloropyrazine-2-carboxylic acid yielding 3,5-diamino-6-chloro-N-(4-(piperidin-1-yl)pyridin-3-yl)pyrazine-2-carboxamide (76%). LCMS (m/z): 347.8 (MH+); LC Rt=2.17 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822497B2
Source datasetuspto-grants-2014_09
ORD IDord-af38a5590b224de7a50c26858eb0f239
Source noteuspto-grants-2014_09