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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 69901Generated: October 28, 2026

(+/-)-Tert-butyl 4-fluoro-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate → (+/-)-Tert-butyl 1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate

https://huagongshe.com/reaction/69901

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(+/-)-Tert-butyl 4-fluoro-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamateHCID 76773285—
SolventEthanolHCID 702—
SolventEthyl AcetateHCID 8857—
Product(+/-)-Tert-butyl 1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-ylcarbamateHCID 7677328799%

Reaction Steps

Following Method 2 of Example 49, (+/−)-tert-butyl 4-fluoro-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate in ethanol and ethyl acetate (1:1, 0.1 M solution) was reduced yielding (+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate, (>99%). LCMS (m/z): 311.2 (MH+); LC Rt=2.14 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822497B2
Source datasetuspto-grants-2014_09
ORD IDord-4d25aa0af77c474488a5f504e29ac43f
Source noteuspto-grants-2014_09