HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 77419826, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (+/-)-Tert-butyl 4,4-difluoro-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate | HCID 77419823 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 77419826 | HCID 77419826 | 99% |
Reaction Steps
Following Method 2 of Example 49, (+/−)-tert-butyl 4,4-difluoro-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate and triethylamine in ethanol and ethyl acetate (1:1, 0.1 M solution) was reduced yielding (+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-4,4-difluoropiperidin-3-ylcarbamate, (>99%). LCMS (m/z): 329.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ecf34a73489b4b4f898bec0460fffc08 |
| Source note | uspto-grants-2014_09 |