Potassium Cation → 1-[2-(4-Azido-3-hydroxypiperidin-1-yl)ethyl]-5,7-difluoroquinolin-2-one

HRID 699131Notes

Reaction equation

HRID 699131 reaction equation
[C:62](=[O:63])([O-:64])[O-:65].[CH3:16][S:17]([O:18][CH2:21][CH2:22][N:23]1[CH2:24][CH:25]([OH:32])[CH:26]([N:29]=[N+:30]=[N-:31])[CH2:27][CH2:28]1)(=[O:19])=[O:20].[F:1][c:2]1[c:3]2[cH:4][cH:5][c:6](=[O:13])[nH:7][c:8]2[cH:9][c:10]([F:12])[cH:11]1.[F:33][c:34]1[c:35]([F:36])[c:37]2[c:38]([cH:39][cH:40][c:41](=[O:42])[n:43]2[CH2:44][CH2:45][N:46]2[CH2:47][CH2:48][CH:49]([NH:50][C:51](=[O:52])[O:53][C:54]([CH3:55])([CH3:56])[CH3:57])[CH2:58][CH2:59]2)[cH:60][cH:61]1.[H-:14].[K+:66].[K+:67].[Na+:15]>>[F:1][c:2]1[c:3]2[cH:4][cH:5][c:6](=[O:13])[n:7]([CH2:21][CH2:22][N:23]3[CH2:24][CH:25]([OH:32])[CH:26]([N:29]=[N+:30]=[N-:31])[CH2:27][CH2:28]3)[c:8]2[cH:9][c:10]([F:12])[cH:11]1

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 923Sodium ionHCID 19660Carbonate IonHCID 166653HydrideHCID 642082495,7-Difluoro-1,2-dihydroquinolin-2-oneHCID 86642603tert-butyl{1-[2-(7,8-difluoro-2-oxoquinolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamateHCID 910422672-(4-Azido-3-hydroxypiperidin-1-yl)ethyl methanesulfonate

Product 1

HCID 1233822641-[2-(4-Azido-3-hydroxypiperidin-1-yl)ethyl]-5,7-difluoroquinolin-2-one

Sources & evidence

ORD record
ord-fb79736aa40b48e2ad226fa7c736174a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…