Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-4-(3-(tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine → tert-butyl(S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-4-(3-(tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine | HCID 68160972 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | tert-butyl(S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine | HCID 86669191 | — |
반응 단계
Following Method 2 of Example 49, (R)-4-(3-(tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine in ethanol was reduced yielding tert-butyl (S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine. LCMS (m/z): 308.2 (MH+); LC Rt=3.47 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-11ab70d2f5ca4b6c9af1277e89f45388 |
| 출처 메모 | uspto-grants-2014_09 |