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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 69919생성일: 2026년 10월 25일

3-Amino-6-bromopicolinic acid → 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide

https://huagongshe.com/reaction/69919

반응식

참여 물질

역할이름HCID투입량
반응물3-Amino-6-bromopicolinic acidHCID 45480452—
반응물Tert-butyl (+/-)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amineHCID 86669190—
생성물3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamideHCID 86669192—

반응 단계

Following Method 11 of Example 305, tert-butyl (+/−)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine was coupled to 3-amino-6-bromopicolinic acid yielding 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide. LCMS (m/z): 506.2 (MH+); LC Rt=4.03 min.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08822497B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-e505b33323204771ad894a072c0bbfe6
출처 메모uspto-grants-2014_09