3-Amino-6-bromopicolinic acid → tert-butyl (3R,4R)-1-(3-(3-amino-6-bromo-picolinamido)pyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-yl-carbamate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3-Amino-6-bromopicolinic acid	HCID 45480452	—
Edukt	tert-butyl (3R,4R)-1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate	HCID 58386806	—
Produkt	tert-butyl (3R,4R)-1-(3-(3-amino-6-bromo-picolinamido)pyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-yl-carbamate	HCID 86669208	27%

Reaktionsschritte

Following Method 11 of Example 305, trans-(+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate and 3-amino-6-bromo-picolinic acid was reacted yielding trans-(+/−)-tert-butyl 1-(3-(3-amino-6-bromo-picolinamido)pyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate, (27%). LCMS (m/z): 621.2 (MH+); LC Rt=4.41 min.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08822497B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-ce42e1455aa94424bf615b2ed81b88b6
Quellennotiz	uspto-grants-2014_09