HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-6-bromopicolinic acid → trans-(+/-)-Tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-3-(tert-butyldimethylsilyloxy)piperidin-4-yl-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Reactant | trans-(+/-)-Tert-butyl 1-(3-aminopyridin-4-yl)-3-(tert-butyldimethylsilyloxy)piperidin-4-ylcarbamate | HCID 68184619 | — |
| Product | trans-(+/-)-Tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-3-(tert-butyldimethylsilyloxy)piperidin-4-yl-carbamate | HCID 88862445 | 20% |
Reaction Steps
Following Method 11 of Example 305, trans-(+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-3-(tert-butyldimethylsilyloxy)piperidin-4-ylcarbamate and 3-amino-6-bromo-picolinic acid was reacted yielding trans-(+/−)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-3-(tert-butyldimethylsilyloxy)piperidin-4-yl-carbamate, (20%). LCMS (m/z): 623.2 (MH+); LC Rt=4.12 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-2a8990aa76cf4543876a3580a9d6ca16 |
| Source note | uspto-grants-2014_09 |