1,4-Dioxane → 1,1-Dimethylethyl 4-[4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-2-yl]-piperidinecarboxylate

HRID 699365Notes

Reaction equation

HRID 699365 reaction equation
[CH2:45]1[O:46][CH2:47][CH2:48][O:49][CH2:50]1.[CH3:42][Zn:43][CH3:44].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:26]3[c:27]([F:41])[c:28]([NH:32][S:33](=[O:34])(=[O:35])[c:36]4[cH:37][o:38][cH:39][cH:40]4)[cH:29][cH:30][cH:31]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1>>[c:2]1([CH3:42])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:26]3[c:27]([F:41])[c:28]([NH:32][S:33](=[O:34])(=[O:35])[c:36]4[cH:37][o:38][cH:39][cH:40]4)[cH:29][cH:30][cH:31]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 579900091,1-Dimethylethyl 4-(5-(2-chloro-4-pyrimidinyl)-4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-1-piperidinecarboxylateHCID 178477796HCID 178477796, compound

Product 1

HCID 579900741,1-Dimethylethyl 4-[4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-2-yl]-piperidinecarboxylate

Sources & evidence

ORD record
ord-5dbdfc7fd248471481591fa08c37c935
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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