HRID69941

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53401194

6-Bromo-5-fluoropyridine-2-carboxylic acid

C6H3BrFNO2

结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2N)C1

HCID59332360

tert-Butyl [(3S)-1-(3-aminopyridin-4-yl)piperidin-3-yl]carbamate

C15H24N4O2

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2NC(=O)c2ccc(F)c(Br)n2)C1

HCID86669196

1,1-Dimethylethyl N-[(3S)-1-[3-[[(6-bromo-5-fluoro-2-pyridinyl)carbonyl]amino]-4-pyridinyl]-3-piperidinyl]carbamate

C21H25BrFN5O3

PROCEDURE

实验过程

Following Method 11 (Example 305), (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate was coupled to 6-bromo-5-fluoropicolinic acid yielding crude (S)-tert-butyl 1-(3-(6-bromo-5-fluoropicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate (92%) which was used as is. LCMS (m/z): 496.2 (MH+); LC Rt=2.90 min.