Potassium Cation → 1-(2-(3-(((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)methyl)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one

HRID 699469Notes

Reaction equation

HRID 699469 reaction equation
[C:42](=[O:43])([O-:44])[O-:45].[CH3:40][OH:41].[K+:46].[K+:47].[O:1]1[CH2:2][CH2:3][O:4][c:5]2[cH:6][n:7][c:8]([CH2:11][N:12]([C:13](=[O:14])[C:15]([F:16])([F:17])[F:18])[CH2:19][CH:20]3[CH2:21][N:22]([CH2:26][CH2:27][n:28]4[c:29](=[O:39])[cH:30][cH:31][c:32]5[n:33][cH:34][c:35]([F:38])[cH:36][c:37]45)[CH2:23][CH2:24][CH2:25]3)[cH:9][c:10]21.[OH2:48]>>[O:1]1[CH2:2][CH2:3][O:4][c:5]2[cH:6][n:7][c:8]([CH2:11][NH:12][CH2:19][CH:20]3[CH2:21][N:22]([CH2:26][CH2:27][n:28]4[c:29](=[O:39])[cH:30][cH:31][c:32]5[n:33][cH:34][c:35]([F:38])[cH:36][c:37]45)[CH2:23][CH2:24][CH2:25]3)[cH:9][c:10]21

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 887MethanolHCID 962WaterHCID 19660Carbonate IonHCID 57815282N-(2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)-2,2,2-trifluoro-N-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-3-ylmethyl)acetamide

Product 1

HCID 578153161-(2-(3-(((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)methyl)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-2ead6accaeb34ec8bf34103f6274be36
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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