HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chloro-6-methylpyrimidine → 4-Chloro-n,n-di-boc-6-methylpyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 4-Chloro-n,n-di-boc-6-methylpyrimidin-2-amine | HCID 58395746 | — |
Reaction Steps
Method 24 was followed using 4-chloro-6-methylpyrimidin-2-amine (1.0 equiv.), BOC2O (2.0 equiv.), and DMAP (cat.) to afford 4-chloro-N,N-di-BOC-6-methylpyrimidin-2-amine in 71%. LCMS (m/z): 344.2 (MH+); LC Rt=4.3 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4e69f75b88c7414ba88fdc4f50c19346 |
| Source note | uspto-grants-2014_09 |