HRID69955

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID49760414

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine

C11H17BN2O2

结构：COc1ccc(CNc2cc(I)cc(C(F)(F)F)n2)cc1OC

HCID69047366

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CNc2cc(-c3ccncc3N)cc(C(F)(F)F)n2)cc1OC

HCID68161531

N2-[(3,4-Dimethoxyphenyl)methyl]-6-(trifluoromethyl)[4,4′-bipyridine]-2,3′-diamine

C20H19F3N4O2

收率 38%

AUXILIARIES

试剂、催化剂与溶剂

结构：ClCCl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1

催化剂HCID178418807

未命名化合物

溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

Method 26 was followed using N-(3,4-dimethoxybenzyl)-4-iodo-6-(tri-fluoromethyl)pyridin-2-amine (1.0 equiv.), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (3 equiv.), Pd(dppf)Cl2 DCM (0.10 equiv.) in DME/2M Na2CO3 (3:1, 0.07 M) at 50° C. for 45 min. Purification via reverse phase HPLC afforded N2-(3,4-dimethoxybenzyl)-6-(trifluoromethyl)-4,4′-bipyridine-2,3′-diamine in 38% yield. LCMS (m/z): 402.1 (MH+); LC Rt=3.0 min.

WORKUP

后处理

customat 50° C.
customfor 45 min
customPurification via reverse phase HPLC